Hormone Pellet Therapy: What You Need to Know

Mandy Cotten DNP, APRN, FNP-C | Institute For Hormone Balance
ATE 2025 Block

Q&A

Hormone Pellet Therapy

What is hormone pellet therapy?

Hormone pellet therapy is a form of bioidentical hormone replacement therapy (BHRT) that uses tiny, custom-compounded pellets inserted just under the skin to release hormones gradually over time. These pellets contain either estrogen, testosterone, or a combination, and mimic the body’s natural hormone levels more closely than synthetic versions.

Who is a good candidate for hormone pellet therapy?

Men and women experiencing symptoms of hormonal imbalance may be good candidates. These symptoms can include:

  • Fatigue or low energy
  • Mood swings or irritability
  • Low libido
  • Weight gain
  • Trouble sleeping
  • Mental fog or memory loss

What are the benefits compared to other forms of hormone therapy?

Pellet therapy offers several advantages:

  • Steady hormone levels: Unlike pills or creams that can cause fluctuations, pellets release hormones consistently.
  • Convenient: No daily medications or messy gels—just one treatment every few months.
  • Customized: Each pellet is tailored to your body’s specific needs based on lab results.
  • Improved symptom relief:  Many patients report better mood, energy, and sexual function within weeks.

How are the pellets administered?

The procedure is quick and performed in a medical office. A healthcare provider numbs a small area (usually the upper hip or buttock), makes a tiny incision, and inserts the pellet under the skin. The incision is closed with a small bandage—no stitches needed. The pellet then slowly releases hormones into the bloodstream over the next 3–6 months.

How soon will I notice results from hormone pellet therapy?

Most patients notice improvements within 7 to 10 days after pellet insertion, though full results typically take 2 to 4 weeks to develop. Benefits often include increased energy, better sleep, enhanced mood, mental clarity, and improved libido. Since the therapy delivers a steady, consistent hormone level, many people report a smoother, more natural improvement compared to other forms of hormone replacement.

How often do I need to get hormone pellet therapy?

On average, men and women receive pellet therapy every 3 to 4 months, while men typically need it every 5 to 6 months. The exact timing depends on your hormone levels, how your body metabolizes the pellets, and how long symptom relief lasts for you. Regular follow-up appointments and lab work help your provider fine-tune your treatment schedule to keep you feeling your best.

Are the hormones used in pellets natural?

Yes, the hormones are bioidentical, meaning they are chemically identical to those produced by your body.  

About The Expert

Mandy Cotten DNP, APRN, FNP-C Institute For Hormone Balance
Mandy Cotten DNP, APRN, FNP-C
Institute For Hormone Balance

Mandy Cotten is a trailblazer in modern wellness. Known for staying at the forefront of medical innovation, she brings the latest in hormone pellet therapy, and advanced aesthetic procedures to her patients. Now, she’s introducing EXOMIND Therapy—a breakthrough in brain-based care that’s already transforming lives. This cutting-edge technology is what everyone’s talking about—and Mandy is leading the way once again.

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